Basically the ASUS Maximus VI Extreme's Layout has been very well thought. Once more practical are the angled SATA connectors as well as the power- and reset-buttons. There is also a debug display which is very useful in case you should have issues with a component in your system or the board itself. Even the placement of the PCI-Express x16 is very well chosen. There is a total of five full sized PCI Express slots and four of these slots have been wired to a PEX8747 bridge chip. Between these four slots there is one other slots or free space. In this case it is possible to build a Quad SLI setup without running into issues. Apart from that there is generally a lot of space on this board since, it hasn't been squeezed to the rim with features. Should you use this board for extreme overclocking, then you'll find it easy to isolate. Are you a gamer and you want to install a big CPU cooler, then there is plenty of space to even install todays biggers air coolers.