Generally the ASUS P8Z68-VPro's Layout has been very well thought. Once more practical are the angled SATA connectors as well as the power- and reset-buttons. Unfortuntately there is no debug display which would have been very useful in case you should have issues with a component in your system or the board itself. Furthermore the placement of the third PCI-Express slot isn't perfect. We would have love to see it as the second last expansion sloat onboard but in with the P8Z68-VPro it is the last and therefore when a dual slot video card is being installed in the last PCI-Express x16 slot it will cover the connectors at the bottom edge of the board. Unfortunately as we already phrased out in the text above there are some issues if you focus on the CPU socket. The aluminium blocks which keep the current converters cool can cause compatibility problems with high end CPU coolers. Another thing is the DIMM slots. They are also very close to the socket. In this case memory which is equipped with big heatspreaders can also collide with big aircoolers.