Generally the MSI Z77 MPower's layout has been well thought. Once more practical are the angled SATA connectors that you can find on almost all motherboards now out there but MSI added something more, they also angled the USB3 connector. There are also practical power- and reset-buttons along with a clr_CMOS which one is on the back panel very accessible. Furthermore there even is a debug display which is very useful in case you should have issues with a component in your system or the board itself. Totally you find three PCI Express Gen3 x16 slots, which have been very well positioned. Between the two main PCIe 16x you will find two slot space to provide good airflow for a simple dual graphics card setup. I don't think you will make more than a two graphics card setup with this motherboard anyway because SLI is only up to two cards (8x/8x) and only CrossFire is up to three cards (8x/4x/4x). Otherwise you have four PCIe Gen2 x1 connectors.
MSI provided also their board with Wi-Fi and Bluetooth modules, the rest is almost standard (six USB3, four SATA3, two SATA2, one internal USB3 connector (for two USB3 ports) and so).
As MSI's overclocking motherboard you get voltage reading points, OC Genie buttons and two physical BIOS with a switch to select the one you want.